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John C. Bischof |
Ph.D., 1992, Mechanical Engineering, University of California, Berkeley M.S., 1989, Biomedical Engineering, University of California, Berkeley and San Francisco (Joint Program) B.S., 1987, Biomedical Engineering, University of California, Berkeley |
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The bioheat and mass transfer laboratory at the University of Minnesota under the direction of Dr. Bischof is dedicated to the thermophysical and biological study of systems after thermal manipulations (i.e. heating or cooling). This work is broadly in the scientific areas of cryobiology (low temperature biology) and hyperthermic biology and impacts the following applications:
The low temperature applications include preservation of cells and tissues in the frozen, dried or glassy state for transplantation. Systems of study include sperm, oocyte, cardiovascular and engineered tissues. In addition, we study the destructive effects of freezing on tissues and tumors of a variety of organs including liver, prostate, breast and kidney by a technique known as cryosurgery. This work also has application in the areas of frost bite and hypothermic injury. Supraphysiological (high) temperature applications include the characterization of thermal and electrical burns particularly to the skin and underlying tissue. In addition, minimally invasive thermal surgery using microwave, radiofrequency and high intensity focused ultrasound of both diseased and normal heart, liver, brain, prostate and other tissues are areas of active pursuit. In brief the lab focuses on basic aspects of thermal injury as well as applied work in the characterization and development of devices for preservation and destruction using heat or cold.
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